Mitochondrial dysfunction is associated with the etiologies of sensorineural hearing loss, such as age-related hearing loss, noise- and ototoxic drug-induced hearing loss, as well as hearing loss due to mitochondrial gene mutation.Mitochondria are the main sources of reactive oxygen species (ROS) and ROS-induced oxidative stress is involved in coch

Sequencing-based interrogation of gut microbiota is a valuable approach for detecting microbes associated with colorectal cancer (CRC); however, such studies are often confounded by the effect of bowel preparation.In this study, we evaluated the viability of identifying CRC-associated mucosal bacteria through centimeter-scale profiling of the micro

Due to the expansion of ethanol production, debate on conflicting issues regarding land use competition between biofuels and food production is raised.Integrated sugarcane/livestock systems could potentially facilitate the expansion of ethanol production without putting crop and/or livestock production at risk and displacing areas covered with natu

Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections.The bacterial type IIA topoisomerases, DNA gyrase and topoisomerase IV, are validated antibacterial drug targets with multipl

Dengue is endemic in more than 100 countries in Southeast Asia, the Americas, the western Pacific, Africa and the eastern Mediterranean regions.The virus is transmitted by Aedes mosquitoes.Dengue disease is Travel Cups the most prevalent arthropodborne viral disease in humans and is a global and national public health concern in several countries.A